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Dr Joseph Bonventre

He has had a long-standing interest in various aspects of cellular injury and repair mechanisms in the kidney with a special emphasis on the role of inflammation, biomarkers and stem cells.

His team has a great deal of experience with various animal models of AKI and chronic kidney disease and their work has been cited more than 43,500 times. He has a citation h-index of 109 and has received two MERIT awards from NIH and serves on NIH Council.

The team have extended their repair and stem cell work to creation of induced pluripotent stem (iPS) cells and the development of an approach to differentiate iPS and embryonic stem cells to cells of the kidney lineage. They published the first demonstration of creation of an iPS cell line from a kidney disease, polycystic kidney disease, which has an abnormality with plausible significance with respect to the etiology of the disease.  iPS cells generated from fibroblasts of humans with autosomal dominant PKD had reduced ciliary levels of polycystin-2 which could be rescued in iPS-derived hepatoblasts by overexpression of polycystin-1.

This work opened up the possibility to conduct “kidney clinical trials in a dish” with patient specific cells that can by evaluated for efficacy of potential therapeutic agents. They also recently reported a rapid and efficient process, derived by techniques guided by principles of kidney development, by which human iPS and ES cells can be differentiated into intermediate mesoderm and subsequently form multisegmented kidney structures containing podocalyxin expressing cell clusters surrounded by a epithelial layer mimicking Bowman’s capsule, flowing into a continuous tubular structure with properties of proximal tubule, followed by loop of Henle and distal convoluted tubule.

« Professor Jim Mann
Professor Roger Stupp »

Cardiology, Diabetes & Nephrology at the Limits Canada
Wednesday, 3 & Thursday, 4 March 2021, Virtual Meeting

Cardiology, Diabetes & Nephrology at the Limits 2021
Monday, 12 & Tuesday, 13 April 2021, Virtual Meeting

The 18th Malvern Diabetic Foot Conference
Wednesday, 12 – Friday, 14 May 2021, Malvern, UK

Multiple Sclerosis Nurses
at the Limits

Friday, 10 & Saturday, 11 September 2021, London, UK

Multiple Sclerosis at the Limits
Monday, 13 & Tuesday, 14 September 2021, London, UK

Hatter Horizon GP Meeting
Monday, 1 November 2021
London, UK

Cell Therapy at the Limits 2021
Monday, 8 & Tuesday, 9 November 2021, London, UK

Hatter Horizon Series
Monday, 22 November 2021, London, UK

Cardiology, Diabetes & Nephrology at the Limits Brazil
Friday, 10 - Saturday, 11 December 2021, São Paulo, Brazil

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